Tourist routes:

Day 1: Taishan Pumice Village (on a specific date, you can watch the parade of pumice floating in color)-Jingmei Village ("punch in" Cai Lifo’s kungfu wall painting, and the training hall learns to play Cai Lifo’s boxing).

The next day: the Chenpi Ancient Road (Chenpi Cultural Experience Hall) displays the growth process of citrus trees and the processing process of Xinhui Chenpi in an all-round way. Close contact with the collection of dried tangerine peel, authentic dried tangerine peel banquet)-Lee Kum Kee Xinhui production base (experience Lee Kum Kee’s ancient oyster cooking culture)

Non-legacy items: [Taishan pumice floating color] (national non-legacy)

Punching point: Fushi Village, Taishan

The floating color of pumice began in the late Ming and early Qing dynasties, and it has a history of more than 300 years. The genealogy of pumice has been officially recorded in the 14th year of Guangxu reign (AD 1888). Every year, on the third day of the third lunar month (the birthday of the Northern Emperor), the villagers of Pumice lined up from the Northern Emperor Temple in the village, carrying the statue of the Northern Emperor to travel to 10 Pumice Square (10 natural villages), and added fun to the fun with floating colors, praying for good weather and good harvests. In June 2008, the floating color of pumice was selected into the second batch of national intangible cultural heritage list.

Chen Fanghuan photo

Non-legacy projects:[Cai Lifo Boxing] (National Heritage)

Punch point: Jingmei Village

Cai Lifo’s disciples gave a wonderful performance at the literary evening to commemorate the 200th anniversary of Chen Xiang’s birth and the 170th anniversary of Cai Lifo’s boxing.

Non-legacy items: [Processing Techniques of Xinhui Chenpi] (National Non-legacy)

Punching point: Chenpi Ancient Road

Sun dried tangerine peel Peng Weizong photo

Xinhui tangerine peel processing technique is a traditional medicinal material processing technique passed down from generation to generation in Xinhui District, Jiangmen City, Guangdong Province. Xinhui tangerine, a local specialty, is carefully made into Xinhui tangerine peel for medical use and daily cooking. Xinhui Chenpi is one of the top ten southern medicines in Guangdong. In 2016, it became the first batch of Guangdong Lingnan Chinese herbal medicines to be protected by legislation. The Compendium of Materia Medica and Manual of Traditional Chinese Medicine all recorded the medicinal functions of Xinhui Chenpi, which has the functions of invigorating qi and spleen, eliminating dampness and resolving phlegm.

Peng Weizong photo

The technological process of Xinhui tangerine peel processing includes picking, peeling, peeling, peeling, sun drying and aging: picking in three periods when the peel color is turquoise, reddish and scarlet; Cleaning adopts "two-knife method" or "three-knife method" to open the skin, with shallow, slow and soft cutting, deep, steady and fast cutting, shallow, light and slow cutting, with fruit pedicles connected and three petals peeled evenly; After opening, the peel is dried in the shade for 6 hours, and the peel is quickly reversed manually after the skin becomes soft; Turn over the skin after drying in the sun until it is half dry, and collect the skin when drying until it is hard; Temperature and humidity should be strictly controlled during storage and aging. Bags or straw mats should be used for packaging. When stacking, "the bottom does not depend on the ground, the edge does not depend on the wall, and the top does not depend on the top". New skins less than three years old should be sun-dried for 5-6 hours in sunny days from June to November every year, and put into storage for aging from November to May of the following year. After three years of repetition, it became Xinhui Chenpi.

In June, 2021, the State Council announced the fifth batch of national intangible cultural heritage representative project list (185 items in total) and the expanded project list of national intangible cultural heritage representative project list (140 items in total). Among them, the processing technology of Xinhui Chenpi recommended by Jiangmen City, as one of the expansion items of traditional Chinese medicine processing technology, was selected into the expanded project list of national intangible cultural heritage representative projects.

Walking into the ancient tangerine peel road, you can learn about the history, culture and production process of tangerine peel.

If you want to know the processing skills of Xinhui Chenpi, go to Chenpi Ancient Road ~

The Chenpi Ancient Road is invested by Jiangmen Ligong Agricultural Development Co., Ltd., which is divided into professional areas such as Chenpi Special Catering Area, Xinhui Chenpi and Ganpu Tea Culture Museum Area. On the unique "Old Pericarpium Citri Tangerinae Road", visitors will be fully introduced and shown the culture of Xinhui Pericarpium Citri Tangerinae through physical objects, acousto-optic images and other means, showing the production technology of Pericarpium Citri Tangerinae, the production technology of citrus tea, the samples of Pericarpium Citri Tangerinae from various production areas in different years, the development history of Pericarpium Citri Tangerinae, the medicinal situation of Pericarpium Citri Tangerinae, etc. You can also learn about the professional storage warehouses of Pericarpium Citri Tangerinae and appreciate the splendid culture of Pericarpium Citri Tangerinae for thousands of years through the open industrial corridor

Non-legacy items: [Lee Kum Kee oyster sauce making skills] (provincial non-legacy)

Punch point: Lee Kum Kee Xinhui production base (experience Lee Kum Kee’s ancient oyster cooking culture)

Source: Jiangmen Intangible Cultural Heritage Protection Center　

The birth of Lee Kum Kee’s oyster sauce production technique is closely related to the fact that the Pearl River Port has long been an important "oyster town" along the southeast coast of China. At the latest in the Song and Yuan Dynasties, the "shallow bottom oyster culture method" was cultivated in the Pearl River Estuary, and many oyster fields were formed from Shenzhen and Hong Kong on the east coast to Macao and Xiangshan on the west coast. Macao was formerly called "Haojing ‘ao" and "Haojiang", and the word "Hao" was derived from "oyster".

Lee Kum Kee’s oil-consuming production has four technological processes: "cultivating oysters-selecting materials to open oysters-decocting oyster juice-secret oyster sauce". The production mechanism revealed by the experience, knowledge and skills accumulated in the past 100 years from oysters to oyster sauce is technically difficult and highly confidential, which is the most critical intangible cultural heritage element and the core competitive technology of Lee Kum Kee oyster sauce. In 2021, oyster sauce production technology was selected into the eighth batch of representative projects of provincial intangible cultural heritage.

Source: Jiangmen Intangible Cultural Heritage Protection Center　

Lee Kum Kee’s oyster sauce production skills are mainly passed down and used in Xinhui District, Guangdong Province, Hong Kong and Macao, which is a historical witness to the development of Guangdong-Hong Kong-Macao Greater Bay Area culture with the same origin and the same body. It is exported to all parts of the world through the Maritime Silk Road, which is a cultural link to comfort homesickness and unite overseas Chinese. It spreads Chinese food culture, promotes the exchange and integration of Chinese and foreign seasoning cultures, and has outstanding historical value, scientific value, irreplaceable cultural significance and social function.

除了打卡特色非遗路线，

你还可以到江门市文化馆

打卡非遗摄影展哦~

1. In the medical expenses for serious illness, taxpayers are hospitalized at the end of the year and discharged at the beginning of the second year. How to calculate the deduction for such inter-annual medical expenses? Is it deducted separately in two years?

A: Taxpayers are hospitalized at the end of the year and discharged at the beginning of the following year. Generally, medical expenses are settled when they are discharged. Taxpayers who claim to enjoy medical deduction for serious illness shall be subject to the settlement time on the medical expense settlement form. Therefore, the medical expense expenditure belongs to the second year.

For example, if a taxpayer is hospitalized at the end of 2022 and discharged at the beginning of 2023, he can enjoy the deduction in 2024 if he meets the conditions of medical deduction for serious illness by the end of 2023.

2. Can I enjoy the deduction when I see a doctor in a private hospital?

Answer: For private hospitals included in the medical insurance settlement system, as long as the taxpayer’s medical expenses can be reflected and collected in the medical insurance system, the taxpayer’s expenses related to basic medical insurance can be deducted for serious illness according to regulations.

3. The husband and wife have serious medical expenses at the same time. If both of them are deducted from the husband, what is the deduction limit?

Answer: Husband and wife have eligible medical expenses for serious illness at the same time, so they can choose to deduct both of them from the husband’s side. The deduction limit is calculated separately. The maximum deduction for each person is 80,000 yuan, and the total maximum deduction limit is 160,000 yuan.

4. Special additional deduction for serious illness medical treatment, is it also necessary to deduct medical expenses for hospitalization, and medical expenses without hospitalization cannot be used as special additional deduction?

A: According to the Interim Measures, the medical expenses incurred by taxpayers related to basic medical insurance, after deducting the personal burden after medical insurance reimbursement (referring to the self-paid part within the scope of medical insurance catalogue), are deducted within the limit of 80,000 yuan. In other words, the medical expenses for serious illness only need to meet the above conditions, regardless of whether the taxpayer is hospitalized.

5. Does the out-of-pocket part of the medical deduction for serious illness include the out-of-pocket part under the deductible line of medical insurance reimbursement?

A: There is no provision for the deductible line of medical insurance reimbursement in the special additional deduction policy for serious illness medical care, so as long as it belongs to the deductible part within the scope of medical insurance catalogue.

6. How to inquire about medical expenses for serious illness?

A: You can download the "National Medical Insurance Service Platform" through your mobile phone, and after registration, you can query it through the "Annual Expense Summary Query" module on the home page. You can also fill in according to the medical service charges of seriously ill patients and the self-paid amount of personal burden within the scope of medical insurance catalogue on the bills related to medical insurance reimbursement.

Original title: "Error-prone points of special additional deduction for individual tax-medical treatment for serious illness"

Read the original text

　　1. (000027) Shenzhen Energy: Supplement to the proposal of the second extraordinary shareholders’ meeting in 2008.

　　On March 25, 2008, Shenzhen Energy received a letter from Shenzhen Energy Group Co., Ltd. (the controlling shareholder of the company, holding 63.74% of the company’s shares), requesting the second extraordinary shareholders’ meeting in 2008 to consider the Proposal on Bidding for the Land of Shenzhen Energy Headquarters Building.

　　According to relevant regulations, the company submitted the new proposal to the second extraordinary general meeting of shareholders held on April 7, 2008 for consideration.

　　2. (000034)SST Shentai: The second prompt for holding the shareholders’ meeting related to the share-trading reform on March 28th.

　　1. Convenor: the board of directors of the company.

　　2. Time for convening the extraordinary shareholders’ meeting and relevant shareholders’ meeting:

　　On-site meeting time: Friday, March 28th, 2008, 9:00-11:30.

　　Online voting time: March 26th, 2008-March 28th, 2008.

　　Among them, the specific time for online voting through the trading system of Shenzhen Stock Exchange is:

　　From March 26th, 2008 to March 28th, 2008, every trading day is from 9: 30 to 11: 30 and from 13: 00 to 15: 00; It ended at 15:00 on March 28th, 2008.

　　The specific time for voting through the Internet is from 9: 30 on March 26th, 2008 to 15:00 on March 28th, 2008.

　　3. date of record: 24 March 2008

　　4. Site meeting place: meeting room of Shenzhen Huabao (Group) Feed Co., Ltd., northwest of the intersection of National Highway 107 and Xixiang Avenue, Baoan District, Shenzhen.

　　5. Meeting mode: combining on-site voting with online voting.

　　6. Matters to be considered at the meeting: Reform Plan of the Company’s Non-tradable Shares

　　3. (000035)ST Kejian: The board of directors passed the proposal of the company to carry out major asset restructuring and purchase assets through non-public offering of shares.

　　The 10th (temporary) meeting of the 4th Board of Directors of ST Kejian was held on March 24th, and the following proposals were considered and passed:

　　I. Proposal on the Company Meeting the Conditions for Non-public Offering of Shares;

　　2. Proposal on the Company’s Major Asset Restructuring and Non-public Offering of Shares to Purchase Assets;

　　3. To request the shareholders’ meeting to approve the proposal that zhu zhiping and his concerted actions are exempted from increasing the company’s shares by way of offer;

　　IV. "About the signing of the company with the Debt Committee, Kejian Group, Zhixiong Electronics, Tongli Company and Mr. Hao Jianxue"<框架协议>Proposal ";

　　V. About the signing of the Company with zhu zhiping, Ji Lisong, Cong Naikang and Tongli Company

　　VI. Proposal on Requesting the General Meeting of Shareholders to authorize the Board of Directors to handle matters related to major asset restructuring and non-public offering;

　　VII. Proposal on Submitting to the General Meeting of Shareholders for deliberation and approval on amending the Articles of Association;

　　VIII. Proposal on Temporarily Not Convening the Company’s General Meeting of Shareholders.

　　The company will hold another meeting of the board of directors to make supplementary resolutions on the above-mentioned related matters, and announce the time for convening the shareholders’ meeting separately.

　　4. (000035)ST Kejian: The first extraordinary general meeting of shareholders in 2008 was held on April 22nd.

　　1. Convening time: April 22nd, 2008 (Tuesday) at 1: 30pm.

　　2. Venue: Meeting room on the second floor of Kejian Building, Gongye Sixth Road, Shekou, Shenzhen.

　　3. Convenor: the board of directors of the company.

　　4. Convening method: on-site voting.

　　5. date of record: April 15, 2008

　　6. Matters to be considered at the meeting:

　　(1) Proposal on electing Mr. Du Changxi as the director of the fourth board of directors of the company;

　　(2) Proposal on reappointing Wuhan Zhonghuan Certified Public Accountants Co., Ltd. as the company’s financial auditing unit in 2007.

　　5. (000157) Zoomlion: The board of directors agreed to acquire the equity of Shaanxi Xinhuanggong Machinery Co., Ltd. and increase its capital.

　　The third interim meeting of the third board of directors of Zoomlion in 2008 was held on March 25th, and the following resolutions were passed:

　　1. Proposal on Acquisition of the Equity of Shaanxi Xinhuanggong Machinery Co., Ltd.;

　　2. Proposal on Capital Increase of Shaanxi Xinhuanggong Machinery Co., Ltd.;

　　III. Proposal on Authorizing the Chairman of the Board of Directors to Handle Stock Purchase, Capital Increase and Other Related Matters.

　　6. (000400) Xu Ji Electric: Main financial indicators and distribution plan of 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.3066.

　　2. Net assets per share (RMB) 5.6331

　　3. ROE (%) 5.44

　　2. Send 1 yuan for every 10 shares (including tax).

　　7. (000421) North Nanjing: Major Events

　　In view of the background of national energy conservation and emission reduction policy, Changzhou Saide Thermal Power Co., Ltd., a holding subsidiary of Nanjing Zhongbei Holding Company, is facing the closure of power business. As Changzhou Saide is a Sino-foreign cooperative enterprise, the company is actively communicating and coordinating with relevant government departments on the above-mentioned power business shutdown and asset disposal, so as to avoid or reduce the possible impact on the company’s operating performance and safeguard shareholders’ rights and interests.

　　8. (000429) Guangdong Expressway A: Major events, the company’s shares will be suspended from March 26th.

　　Guangdong Expressway A is planning major asset restructuring matters, and will provide policy consultation and scheme demonstration to relevant departments within five working days after the publication of this announcement, so there are still uncertainties in related matters.

　　In order to protect the interests of investors and avoid significant impact on the company’s stock price, the company’s stock was suspended from March 26, 2008 upon the company’s application.

　　9. (000488) Chenming Paper Co., Ltd.: It intends to continue to provide guarantee for the relevant holding subsidiaries to apply for the comprehensive credit line of RMB in 2008.

　　On March 24, 2008, the sixth meeting of the fifth board of directors of Chenming Paper reviewed and passed the "Proposal on Providing Guarantee for Holding Subsidiaries to Apply for Bank Credit Line". The 2007 annual credit guarantee provided by the company for its holding subsidiaries has expired one after another. In order to ensure the normal production and operation of each holding subsidiary, the company intends to continue to provide guarantee for the relevant holding subsidiaries to apply for the comprehensive credit line of RMB in 2008, with a total guarantee amount of 2.25 billion yuan and a term of one year.

　　10. (000502) Lvjing Real Estate: Main financial indicators and distribution plan of the 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.0239

　　2. Net assets per share (RMB) 1.08.

　　3. ROE (%) 2.21

　　Second, no distribution and no increase

　　11. (000530) Great Cold B: Abnormal fluctuations in stock trading.

　　The trading price of Dalang B stock was abnormal in the two consecutive trading days from March 24 to 25, 2008, which was a stock price change.

　　At present, the company does not have any matters or information that should be disclosed but not disclosed.

　　12. (000543) Wanneng Electric Power: Main financial indicators and distribution plan in 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.08

　　2. Net assets per share (RMB) 6.82

　　3. ROE (%) 1.21

　　2. Pay 0.85 yuan (including tax) for every 10 shares.

　　13. (000543) Wanneng Electric Power: The 2007 Annual General Meeting of Shareholders was held on April 29th.

　　1. Meeting time: 9:00 am on Tuesday, April 29th, 2008.

　　2. Meeting place: Conference Room 5, 4th floor, Wanneng Building, No.99 Maanshan Road, Hefei, Anhui.

　　3. Convenor of the meeting: the board of directors of the company.

　　4. Method of meeting: On-site voting.

　　5. date of record: April 21, 2008

　　6. Matters considered at the meeting: Report on the Company’s Profit Distribution Plan for 2007, etc.

　　14. (000559) Wanxiang Qian Chao: The annual general meeting of shareholders passed the profit distribution plan for 2007.

　　The 2007 Annual General Meeting of Shareholders of Wanxiang Qian Chao was held on March 25th, 2008, and the following resolutions were passed:

　　1. Work Report of the Board of Directors in 2007.

　　2. Work Report of the Board of Supervisors in 2007.

　　3, 2007 annual financial statements.

　　4. Profit distribution plan for 2007.

　　5. Report on the implementation of related party transactions in 2007 and proposal on the forecast of daily related party transactions in 2008.

　　15. (000565) Chongqing Three Gorges A: The board of directors agreed to provide a one-year working capital loan guarantee of 20 million yuan for the holding subsidiary of Three Gorges Yingli Chemical.

　　The Eighth Board of Directors of the Fifth Session of Chongqing Three Gorges A was held on March 24th, and the proposal to provide a one-year working capital loan guarantee of 20 million yuan for Chongqing Three Gorges Yingli Chemical Co., Ltd., a holding subsidiary of the company, was reviewed and passed.

　　Chongqing Three Gorges Yingli Chemical Co., Ltd. is a holding subsidiary of the company. Its newly-built 50,000-ton glycine/year project is progressing normally and has entered the trial production stage. In order to ensure the completion and production of the project, the company decided to apply for a one-year working capital loan of RMB 20 million from China Merchants Bank Chongqing Branch Jiulongpo Sub-branch, and the company provided guarantee for it.

　　16. (000568) LU ZHOU LAO JIAO CO.,LTD: The performance in the first quarter of 2008 is expected to increase by 250%-300% year-on-year.

　　LU ZHOU LAO JIAO CO.,LTD predicted that the accumulated net profit from January to March 2008 would increase by 250% to 300% compared with the same period of last year, and the net profit attributable to shareholders of listed companies would also increase by more than 250% to 300% compared with the same period of last year.

　　The reasons are:

　　1. The first quarter is the traditional peak season for liquor sales, and the company arranged ahead of schedule. The leading products such as Guojiao 1573 and Luzhou Laojiao Tequ have a good sales situation and the sales volume has increased rapidly;

　　2. As of March 31, 2008, the company held 353,164,800 shares of Huaxi Securities (accounting for 34.86% of the total shares of Huaxi Securities), an increase of 333,164,800 shares compared with the same period of last year, so the investment income increased accordingly.

　　17. (000594) Tianjin Hongfeng: Shenzhen Guoheng sold 8,907,300 shares of the company again.

　　From March 20, 2008 to March 25, 2008, Shenzhen Guoheng Industrial Development Co., Ltd., a shareholder of Tianjin Hongfeng, has sold a total of 8,907,300 shares of the company through listing on Shenzhen Stock Exchange, accounting for 1.59% of the total shares of the company.

　　As of March 25th, 2008, Shenzhen Guoheng still holds 80,686,613 shares (accounting for 14.38% of the total shares of the company).

　　18. (000617) Petroleum firewood: main financial indicators and distribution plan of the 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.41

　　2. Net assets per share (RMB) 2.81

　　3. ROE (%) 14.52

　　2. Send 0.2 yuan for every 10 shares (including tax).

　　19. (000625) Changan Automobile: The 2007 Annual General Meeting of Shareholders was held on April 25th.

　　(1) Convening time: 9:00 am on April 25th, 2008.

　　(II) Venue: Multimedia Meeting Room of Chang ‘an Science and Technology Building, No.260 Jianxin East Road, Jiangbei District, Chongqing.

　　(3) Convenor: the board of directors of the company.

　　(4) Convening method: on-site voting method.

　　(5) date of record: April 18, 2008.

　　(VI) Matters to be considered at the meeting: 2007 annual report and summary, profit distribution in 2007 and plan for converting capital reserve into share capital, etc.

　　20. (000625) Changan Automobile: Main financial indicators and distribution plan in 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.34

　　2. Net assets per share (RMB) 3.89

　　3. ROE (%) 8.81

　　2. Transfer 2 shares for every 10 shares.

　　21. (000631)S*ST Lanbao: The annual report for 2007 will be disclosed before March 29th.

　　S*ST Lanbao’s 2007 financial audit was carried out ahead of schedule, and the audit report will be completed around March 27th, 2008. Therefore, the company’s original time to disclose the 2007 annual report on April 25th, 2008 will be advanced to March 29th, 2008.

　　22. (000652) TEDA Co., Ltd.: Main financial indicators and distribution plan of the 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.35

　　2. Net assets per share (RMB) 1.93.

　　3. ROE (%) 18.24

　　Two, send 3 shares for every 10 shares, and send 0.34 yuan (including tax) to increase 1 share.

　　23. (000652) TEDA: The 2007 annual general meeting of shareholders was held on April 28th.

　　1. On-site meeting time: 2: 00pm on Monday, April 28th, 2008, with a duration of half a day;

　　Online voting time: the online voting time through the trading system is from 9: 30 am to 11: 30 am and from 13: 00 pm to 15: 00 pm on April 28, 2008; The specific time for voting through the Internet voting system of Shenzhen Stock Exchange is from 15:00 pm on April 27th, 2008 to 15:00 pm on April 28th, 2008.

　　2. Venue: Tianjin Tianma International Club Co., Ltd. (address: next to Tianjin Yangliuqing Golf Club, west of Jingfu Highway, Shuangkou Town, Beichen District, Tianjin);

　　3. Convenor: the board of directors of the company;

　　4. Convening method: combining on-site method with online voting;

　　5. date of record: April 21, 2008;

　　6. Matters considered at the meeting: the company’s profit distribution plan for 2007, and the proposal of the company to subscribe for new shares with idle funds in 2008.

　　24. (000655) Jinling Mining: The non-public offering of shares to purchase assets was approved by the state-owned assets management department.

　　Jinling Mining recently received a reply from the State-owned Assets Supervision and Administration Commission of Shandong Provincial People’s Government, agreeing that the company will issue no less than 30 million shares and no more than 50 million shares in a non-public manner to purchase auxiliary assets such as Zhaokou Branch Mine, power plant and some land workshops of Shandong Jinling Iron Mine.

　　25. (000671) Sunshine Development: The 2007 Annual General Meeting of Shareholders was held on April 17th.

　　1. Convenor of the meeting: the board of directors of the company;

　　2. Meeting time: 9:30 am on Thursday, April 17th, 2008;

　　3. Meeting place: Meeting room of Sunshine Holiday Hotel, No.26 Gao Qiao Road, Fuzhou;

　　4. Method of convening the meeting: voting on the spot;

　　5. date of record: April 10, 2008;

　　6. Matters considered at the meeting: The Full Text of the Company’s 2007 Annual Report and its Summary, and the Proposal on the Company’s 2007 Profit Distribution and Converting the Provident Fund into Share Capital, etc.

　　26. (000671) Sunshine Development: Main financial indicators and distribution plan of the 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.18

　　2. Net assets per share (RMB) 2.71

　　3. ROE (%) 6.74

　　2. Pay 0.35 yuan (including tax) for every 10 shares.

　　27. (000677) Shandong Hailong: The performance in the first quarter of 2008 increased by 50%-150% in advance.

　　Shandong Hailong expects that the net profit in the first quarter of 2008 will increase substantially compared with the same period of last year, and it is expected to increase by 50%-150% in the same direction.

　　The reasons are as follows: in the first quarter of 2008, the company was affected by technological upgrading, and the sales of new products increased; In addition, the company’s income from intangible assets and the reduction of income tax rate are affected.

　　28. (000693)S*ST Juyou: The board of directors agreed to hire Zhongyuan International Assets Appraisal Co., Ltd. as an asset appraisal agency.

　　The 24th Board of Directors of the 6th Session of S*ST Juyou held a meeting by fax on March 25th, 2008, and passed the Proposal on Hiring Zhongyuan International Assets Appraisal Co., Ltd. as an Assets Appraisal Agency.

　　29. (000709) Tangshan Iron and Steel Co., Ltd.: The performance in the first quarter of 2008 is expected to increase by 50%-100%.

　　In the first quarter of 2008, the net profit attributable to the owner of the parent company of Tangshan Iron and Steel Co., Ltd. is expected to increase by 50%-100% year-on-year.

　　The reasons are:

　　1. The company increased the cooperation scope of strategic resources and reduced the procurement cost of main raw materials.

　　2. The second phase project of Tangshan Medium Plate Co., Ltd., a holding subsidiary of the company, was put into operation in the first quarter of 2008, which increased the production capacity and benefit.

　　3. The company strives to optimize the variety structure and increase the proportion of high value-added products.

　　4. The company vigorously carried out energy conservation and emission reduction, developed circular economy, deepened benchmarking and tapped potential, and optimized various major economic and technical indicators.

　　30. (000739) Prokangyu: Main financial indicators and distribution plan of the 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.1247

　　2. Net assets per share (RMB) 2.78

　　3. ROE (%) 4.27

　　Second, no distribution and no increase

　　31. (000819) Yueyang Xingchang: Progress of New Drug Evaluation of Gastropathy Vaccine

　　The Drug Evaluation Center of the State Food and Drug Administration held a drug evaluation consultation meeting in Beijing from March 20 to 22, 2008, and conducted an expert evaluation consultation on the "oral recombinant Helicobacter pylori vaccine" (gastropathy vaccine) declared by Chongqing Kangwei Biotechnology Co., Ltd., a subsidiary of Yueyang Xingchang.

　　The review consultation meeting ended on schedule on March 22nd. According to the convention of the consultation meeting, its opinions have not been officially informed to Chongqing Kangwei and announced. According to the website of Drug Evaluation Center of State Food and Drug Administration (website: http://www.cde.org.cn), at present, the consultation and discussion of gastropathy vaccine has ended and entered the stage of "post-consultation review", and "five biological products review rooms are conducting comprehensive evaluation according to the consultation opinions".

　　32. (000819) Yueyang Xingchang: 40,791,244 restricted shares were listed and circulated on March 28th.

　　The number of tradable shares listed under this restricted sale condition is 40,791,244 shares.

　　The circulating date of the tradable shares with limited sale conditions is March 28, 2008.

　　33. (000835) Sichuan Shengda: The board of directors approved the proposal of lending 50 million yuan to hengfeng bank Chengdu Branch, and appointed Chang Feng as the executive deputy general manager of the company.

　　The 24th meeting of the 5th Board of Directors of Sichuan Shengda was held on March 25th, 2008, and the following resolutions were passed:

　　I. Proposal on the Company’s loan of RMB 50 million to hengfeng bank Chengdu Branch.

　　2. To appoint Mr. Chang Feng as the executive deputy general manager of the company.

　　34. (000851) Gaohong Shares: The 2007 Annual General Meeting of Shareholders was held on April 28th.

　　1. Convening time: 9: 00 am on April 28th, 2008.

　　2. venue: meeting room on the third floor of the main building of Datang Telecom Group, No.40 Xueyuan Road, Haidian District, Beijing.

　　3. Convening method: on-site voting method.

　　4. Convenor: Board of Directors

　　5. date of record: April 21, 2008

　　6. Main agenda of the meeting: Proposal of the Company’s 2007 Annual Report and Summary, Proposal of the Company’s 2007 Annual Profit Distribution, etc.

　　35. (000851) Gaohong Co., Ltd.: Main financial indicators and distribution plan of the 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.04

　　2. Net assets per share (RMB) 1.93.

　　3. ROE (%) 2.12

　　Second, no distribution and no increase

　　36. (000897) Jinbin Development: Main financial indicators and distribution plan of the 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.0643.

　　2. Net assets per share (RMB) 1.87.

　　3. ROE (%) 3.43

　　Two, every 10 shares of 0.2 yuan (including tax) increased by 4 shares.

　　37. (000897) Jinbin Development: The performance in the first quarter of 2008 is expected to increase by 50%-100%.

　　Jinbin Development predicts that the net profit in the first quarter of 2008 will increase by 50%-100% year-on-year.

　　In March, 2008, the company received a penalty of RMB 35.286 million from Tianjin TEDA Investment Holding Co., Ltd., which had an impact on the company’s operating performance in the first quarter.

　　38. (000897) Jinbin Development: The 2007 Annual General Meeting of Shareholders was held on April 18th.

　　(1) Meeting time: 10:00 am on Friday, April 18th, 2008.

　　(II) Meeting place: meeting room on the 11th floor of the company.

　　(3) Convenor: the board of directors of the company.

　　(4) Meeting method: voting on the spot.

　　(5) date of record: April 11, 2008.

　　(VI) Matters considered at the meeting: Proposal on the Company’s Profit Distribution Plan for 2007, etc.

　　39. (000901) Aerospace Science and Technology: The disclosure of the 2007 annual report was postponed to April 23rd.

　　Because the annual financial audit of Aerospace Science and Technology could not be completed within the expected time, the disclosure time of the company’s 2007 annual report was postponed to April 23, 2008 with the approval of Shenzhen Stock Exchange.

　　40. (000903) Power in the Cloud: Supplement to the 2007 Annual Report

　　Yunnei Power disclosed its 2007 annual report and abstract on March 8, 2008. In order to enable investors to know more about the company in detail, we now make a supplementary announcement on the relevant contents of the company’s 2007 annual report and abstract.

　　41. (000916) North China Expressway: The 2007 Annual General Meeting of Shareholders was held on April 18th.

　　1. Meeting time: 10:00 am on Friday, April 18th, 2008.

　　2. Meeting place: A301 meeting room of the company.

　　3. Convenor: the board of directors of the company.

　　4. Method of meeting: On-site voting by secret ballot.

　　5. date of record: April 10th, 2008.

　　6. Matters considered at the meeting: profit distribution plan for 2007, etc.

　　42. (000916) North China Expressway: Main financial indicators and distribution plan in 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.286.

　　2. Net assets per share (RMB) 3.46

　　3. ROE (%) 8.27

　　2. Send 1.6 yuan for every 10 shares (including tax).

　　43. (000917) Dianguang Media: 2007 annual performance report, with earnings per share of 0.33 yuan.

　　Main financial data and indicators in 2007:

　　Earnings per share (RMB) 0.33

　　Return on net assets (%) 6.52

　　Net assets per share (RMB) 5.14

　　44. (000917) Dianguang Media: The extraordinary shareholders’ meeting passed the proposal to provide financial support for the holding subsidiaries.

　　The first extraordinary shareholders’ meeting of Dianguang Media in 2008 was held on March 25th, and the Proposal on Providing Financial Support for Hunan Xinfengyuan Investment Co., Ltd., a holding subsidiary, was passed.

　　45. (000931) Zhongguan Village: Major Litigation Progress

　　Beijing Plastics Trading Co., Ltd. and Beijing Longtianlu Real Estate Development Co., Ltd. sued Beijing Zhongguancun Development and Construction Co., Ltd., a holding subsidiary of Zhongguan Village, for the dispute over the infringement of equity transfer. The plaintiffs Plasticizing Company and Longtianlu Company applied to the court to withdraw the lawsuit. The court allowed to withdraw the lawsuit after examination, and the case acceptance fee of 61,866,500 yuan was borne by Plastics Company and Longtianlu Company. This case will not affect the company’s performance in 2007 and 2008.

　　46. (000931) Zhongguan Village: Progress of Major Events

　　After deliberation and approval at the second interim meeting of the third board of directors of Zhongguan Village in 2008, the company decided to suspend the sale of the equity of Beijing Zhongguancun Sihuan Pharmaceutical Development Co., Ltd. and applied to the China Securities Regulatory Commission to withdraw the Report on the Sale of Major Assets and Related Transactions. As the largest shareholder of the company, Pengtai Investment agreed to the company’s decision to suspend the sale of Sihuan Co., Ltd., and promised to buy Sihuan Co., Ltd. again at no less than 400 million yuan when the conditions are ripe. If other potential investors participate in the bidding, the highest bidder will win the bid.

　　On March 25th, 2008, the company received the relevant notice from the China Securities Regulatory Commission, and the China Securities Regulatory Commission decided to terminate the examination of the company’s application.

　　47. (000936) Huaxi Village: The board of directors agreed to acquire 75% equity of Jiangyin Chengyi Storage Co., Ltd. owned by Chenghua International.

　　The 24th Extraordinary Meeting of the Third Board of Directors of Huaxi Village was held on March 25th, and the Proposal on the Company’s Acquisition of 75% Equity of Jiangyin Chengyi Storage Co., Ltd. owned by Chenghua International Co., Ltd. was reviewed and approved.

　　48. (000973) Fosu shares: lease matters.

　　On March 21st, 2008, Fosu Co., Ltd. signed the Workshop and Equipment Lease Contract with Wuxi Zhenghan Iron and Steel Trading Co., Ltd., and the company plans to lease the 9,189.69 square meters workshop and a batch of equipment (including power supply facilities) located at No.226 Fenglin Road, Chancheng District, Foshan City to Zhenghan Company for use.

　　The rent is 1.1 million yuan per year and 1.1 million yuan per year (that is, 91,666.67 yuan/month).

　　The lease term is five years from April 1, 2008 to March 31, 2013.

　　This transaction does not constitute a connected transaction.

　　49. (002001) Xinhecheng: On March 28th, an online briefing on the 2007 annual report was held.

　　Xinhecheng will hold the 2007 annual report briefing session on the online platform provided by Shenzhen Securities Information Co., Ltd. from 15: 00 to 17: 00 on Friday, March 28, 2008. This annual report briefing session will be held by remote network, and investors can visit Panorama: http://irm.p5w.net to participate in the annual report briefing session.

　　Present at the briefing session of this annual report were Mr. Hu Baifan, Chairman of the Company, and others.

　　50. (002030) Daan Gene: Main financial indicators and distribution plan of the 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.28

　　2. Net assets per share (RMB) 2.43

　　3. ROE (%) 11.49

　　2. Send 2 shares for every 10 shares, and send 1.3 yuan (including tax) to increase 4 shares.

　　51. (002030) Daan Gene: The 2007 Annual General Meeting of Shareholders was held on April 16th.

　　(1) Meeting time: starting at 9:30 am on April 16th, 2008.

　　(II) Venue: Lecture Hall, 1st floor, No.19 Xiangshan Road, Guangzhou Economic and Technological Development Zone, Guangdong Province.

　　(III) Convening method: on-site convening.

　　(4) date of record: April 9, 2008

　　(V) Agenda of the meeting: Proposal on Profit Distribution and Capitalization of Capital Reserve Fund in 2007, Annual Report of 2007 and its summary, etc.

　　52. (002036) Yike Technology: The board of directors agreed to invest in the establishment of Ningbo Hanma Industrial Product Development Co., Ltd.

　　The fifth meeting of the third board of directors of Yike Technology was held on March 25th, and it was agreed that the company and the holding company-Hanma Industrial Investment Holding Co., Ltd. jointly invested to establish Ningbo Hanma Industrial Product Development Co., Ltd. The registered capital of Ningbo Hanma Company is RMB 18 million, of which RMB 9 million is contributed by the company, accounting for 50% of the registered capital; Hanma Holdings invested 9 million yuan, accounting for 50% of the registered capital.

　　53. (002048) Ningbo Huaxiang: The performance in the first quarter of 2008 is expected to increase by 60%-90%.

　　Ningbo Huaxiang’s estimated performance in the first quarter of 2008: the net profit attributable to the owners of the parent company increased by 60%-90% compared with the same period of last year.

　　The reasons are:

　　1. The domestic passenger car industry has maintained a rapid development. The company’s main customers, Shanghai Volkswagen, FAW-Volkswagen, Shanghai GM and FAW Toyota, rank in the top ten in sales volume, and the sales volume of the company’s supporting parts has also increased.

　　2. The products supplied by the company have developed in the direction of assembly and modular supply. The batch supply of assembly finished products has improved the matching value of bicycles, thus driving the rapid growth of the company’s sales revenue and profitability.

　　3. The company’s related foreign investment in 2007 generated benefits.

　　54. (002064) huafeng spandex: The transaction fluctuated abnormally.

　　As of March 25th, 2008, the deviation of daily closing price of huafeng spandex stock has reached 20% in three consecutive trading days, which is an abnormal fluctuation of stock trading.

　　The company’s net profit in the first quarter of 2008 is expected to drop by less than 50% compared with the same period of last year. Except for the above matters, the company’s business activities are normal, and there is no information that should be disclosed but not disclosed at present.

　　55. (002065) Donghua Hechuang: The Board of Directors adopted the working rules for the review of the annual report of the Audit Committee of the Board of Directors.

　　The third meeting of the third board of directors of Donghua Hechuang was held on March 25th, 2008, and the following resolutions were passed:

　　1. Measures for the Administration of the Company’s Shares Held by Directors, Supervisors and Senior Management and Their Changes;

　　2. Working Rules for Review of the Annual Report of the Audit Committee of the Board of Directors of the Company;

　　3. Work System for Annual Reports of Independent Directors of the Company.

　　56. (002078) Sun Paper: The board of directors passed the proposal of external guarantee of the company’s holding subsidiary.

　　The 13th Board of Directors of the third session of Sun Paper was held on March 25th, and the Proposal on External Guarantee of the Company’s Holding Subsidiary was reviewed and approved.

　　57. (002083) Vosges shares: The annual general meeting of shareholders adopted the company’s annual report for 2007 and its summary.

　　The 2007 annual general meeting of shareholders of Vosges was held on March 25th, and the following proposals were reviewed and passed:

　　1. Work Report of the Board of Directors for 2007;

　　2. Work Report of the Board of Supervisors in 2007;

　　3. Annual Report of the Company in 2007 and its Summary;

　　4. Report on the Company’s 2007 Annual Financial Statements;

　　5. Proposal on the Company’s Profit Distribution in 2007 and Converting Capital Reserve into Share Capital;

　　6. Proposal on Determining Allowances for Independent Directors;

　　7. Proposal on Remuneration of Directors, Supervisors and Senior Management;

　　8. Proposal on Planning to Apply to Agricultural Development Bank for Comprehensive Credit of not more than 1 billion yuan;

　　9. Proposal on Providing a Total Guarantee of RMB 1.2 billion for Shandong Vosges Photovoltaic Technology Co., Ltd., a wholly-owned subsidiary;

　　10. Proposal on Renewing the Appointment of PricewaterhouseCoopers Zhongtian Certified Public Accountants.

　　58. (002093) Guomai Technology: external guarantee of holding subsidiary.

　　Guomai Zhongxun Network Technology (Hong Kong) Co., Ltd., a wholly-owned subsidiary of Guomai Zhongxun Network Technology Co., Ltd., a holding subsidiary of Guomai Technology, applied to CITIC Ka Wah Bank for a loan with a total amount of no more than US$ 6 million for a period of no more than eight months.

　　On March 25th, 2008, Guomai Zhongxun provided guarantee for the loan that Guomai Zhongxun (Hong Kong) applied for with a total amount of no more than USD 6 million. As of the date of this announcement, Guomai Zhongxun provided guarantee for the loan of Guomai Zhongxun (Hong Kong) with a total amount of USD 14 million (USD: RMB =1:7.09), equivalent to RMB 99.26 million, accounting for the company (including holding subsidiaries).

　　59. (002096) Nanling civil explosion: main financial indicators and distribution plan of 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.635.

　　2. Net assets per share (RMB) 4.74

　　3. ROE (%) 13.39

　　Two, every 10 shares to send 3 yuan (including tax) to increase by 5 shares.

　　60. (002096) Nanling Civil Explosion: The 2007 Annual General Meeting of Shareholders was held on April 21st.

　　(1) Time of the meeting: 9:00 am on April 21st, 2008.

　　(II) Form of meeting: on-site meeting.

　　(3) Place of the meeting: Nanhua Hotel, Yongzhou City, Hunan Province.

　　(4) date of record: April 16, 2008

　　(5) Convenor of the meeting: the board of directors of the company.

　　(VI) Matters to be considered: Plan for Profit Distribution and Capital Reserve Fund Transfer to Share Capital in 2007, Annual Report and Summary of Annual Report of the Company in 2007, etc.

　　61. (002123) Rongxin shares: 23,201,961 shares issued before the initial public offering were listed and circulated on March 28th.

　　The number of shares issued before the initial public offering of Rongxin was 24,953,528, and the actual number of shares available for listing and circulation was 23,201,961. The listing and circulation date was March 28, 2008.

　　62. (002132) Stellar Technology: Prompt for Holding the 2007 Annual General Meeting of Shareholders on March 30th.

　　1. Meeting time: 9:00 am on March 30th, 2008 (Sunday).

　　2. Meeting place: company meeting room.

　　3. Convenor of the meeting: the board of directors of the company.

　　4. Mode of meeting: on-site meeting.

　　5. date of record: March 26th, 2008.

　　6. Meeting topics: 2007 Annual Report and Summary of the Company, 2007 Profit Distribution Plan of the Company, etc.

　　63. (002133) Guangyu Group: 12 million yuan was awarded by the government.

　　According to the relevant documents issued by Shangcheng District People’s Government of Hangzhou on February 3, 2008, in order to encourage the successful listing of Guangyu Group, the government gave the company a listing reward and support of 12 million yuan. The company has recently received this fund.

　　64. (002144) Hongda Warp Knitting: Notice of Holding the 2007 Annual General Meeting of Shareholders on April 18th.

　　(1) Meeting time: 2 pm on Friday, April 18th, 2008.

　　(2) date of record: April 11, 2008

　　(III) Meeting place: conference room on the 10th floor of Hongda Building, No.218 Haizhou Road, Haining.

　　(IV) Method of convening the meeting: voting on the spot.

　　(5) Convenor of the meeting: the board of directors of the company.

　　(VI) Matters considered at the meeting: Company II? ? Full text and abstract of seven-year annual report, Company II? ? Seven-year profit distribution plan of the company, etc.

　　65. (002144) Hongda Warp Knitting: Main financial indicators and distribution plan of 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.23

　　2. Net assets per share (RMB) 2.75.

　　3. ROE (%) 7.09

　　2. Send 1 yuan for every 10 shares (including tax).

　　66. (002151) Big Dipper: Main financial indicators and distribution plan of 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.85.

　　2. Net assets per share (RMB) 4.74

　　3. ROE (%) 14.82

　　Two, every 10 shares of 2.5 yuan (including tax) increased by 7 shares.

　　67. (002151) Big Dipper: The 2007 Annual General Meeting of Shareholders was held on April 16th.

　　1. Meeting time: 9: 00 am on April 16th, 2008.

　　2. Meeting place: the second meeting room of the company.

　　3. Convenor of the meeting: the board of directors of the company

　　4. Method of meeting: On-site voting.

　　5. date of record: 11 April 2008

　　6. Matters to be considered at the meeting: 2007 Annual Report and its summary, 2007 Profit Distribution Plan, etc.

　　68. (002154) Good news bird: the performance in the first quarter of 2008 is expected to increase by 45%-75%.

　　The good news bird predicts that the net profit attributable to the owners of the parent company will increase by 45%-75% in the first quarter of 2008 compared with the same period of last year.

　　The reasons are as follows: with the promotion of brand awareness and reputation, the added value of the brand has increased, the sales revenue has increased, the gross profit margin has increased, and the corporate income tax rate has decreased from 33% to 25%.

　　69. (002165) Hongbaoli: The distribution plan for 2007 was implemented, and every 10 shares were sent to 3 yuan (including tax) and 5 shares were added.

　　Hongbaoli’s profit distribution and capitalization of capital reserve fund in 2007. This plan is to distribute cash bonus 3 yuan for every 10 shares (including tax, after tax deduction, individual shareholders and investment funds actually send 2.7 yuan cash for every 10 shares), and increase 5 shares for every 10 shares.

　　Date of record: April 2, 2008;

　　Ex-dividend date: April 3, 2008;

　　The dividend payment date is April 3, 2008.

　　70. (002167) Dongfang Zirconium Industry: The 2007 Annual General Meeting of Shareholders was held on May 15th.

　　1. Meeting time: 03:00 pm on Thursday, May 15th, 2008.

　　2. Meeting place: conference room on the fourth floor of the company office building.

　　3. Convenor: the board of directors of the company.

　　4. Convening method: on-site voting.

　　5. date of record: May 9, 2008

　　6. Matters considered at the meeting: Profit Distribution Plan of the Company in 2007, Annual Report and Summary of the Company in 2007, etc.

　　71. (002167) Dongfang Zirconium Industry: Main financial indicators and distribution plan in 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.51

　　2. Net assets per share (RMB) 4.29

　　3. ROE (%) 9.74

　　2. Send 0.5 yuan for every 10 shares (including tax).

　　72. (002172) Aoyang Technology: The annual general meeting of shareholders adopted the company’s 2007 annual report and its summary.

　　Aoyang Technology’s 2007 Annual General Meeting of Shareholders was held on March 25th, and the following resolutions were passed:

　　1. Report on the Work of the Board of Directors in 2007;

　　2. Work Report of the Board of Supervisors of the Company in 2007;

　　3. Report on the Company’s 2007 Annual Financial Statements;

　　4. Annual Report of the Company in 2007 and its Summary;

　　5. Special Report on the Use of Funds Raised by the Company in 2007;

　　6. The Company’s 2007 Annual Profit Distribution and the Plan for Converting Capital Reserve Fund into Capital Stock;

　　7. Proposal of the Audit Committee’s Resolution on Renewing the Appointment of Accounting Firms;

　　8. Proposal on Allowances and Expenses of Independent Directors;

　　9. Proposal on Daily Related Party Transactions of the Company in 2008.

　　73. (002185) Huatian Technology: Main financial indicators and distribution plan of the 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.6052

　　2. Net assets per share (RMB) 4.53

　　3. ROE (%) 10.25

　　2. Transfer 5 shares for every 10 shares.

　　74. (002185) Huatian Technology: The 2007 Annual General Meeting of Shareholders was held on April 18th.

　　1. Convenor of the meeting: the board of directors of the company.

　　2. Meeting time: 10:00 am on Friday, April 18th, 2008.

　　3. Meeting place: Meeting room on the 7th floor of Huatian Apartment, No.14 Shuangqiao Road, Qinzhou District, Tianshui City, Gansu Province.

　　4. Voting method at the meeting: on-site voting method.

　　5. date of record: April 11th, 2008.

　　6. Meeting Matters: 2007 Annual Report and Summary, 2007 Profit Distribution and Plan for Converting Capital Reserve into Capital Stock, etc.

　　75. (002189) Lida Optoelectronics: Main financial indicators and distribution plan of the 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.21

　　2. Net assets per share (RMB) 2.26

　　3. ROE (%) 7.03

　　2. Send 0.5 yuan for every 10 shares (including tax).

　　76. (002189) Lida Optoelectronics: The 2007 Annual General Meeting of Shareholders was held on April 20th.

　　I. Meeting time: 9:00 am on April 20, 2008.

　　2. Meeting place: Meeting room on the third floor of Building 103 of the Company.

　　III. Convenor of the meeting: the board of directors of the company.

　　Iv. mode of meeting: voting by on-site voting.

　　V. date of record: April 14, 2008

　　Vi. Matters considered at the meeting: Profit Distribution Plan for 2007, Annual Report for 2007 and Summary of Annual Report for 2007, etc.

　　77. (002194) Wuhan Fangu: Main financial indicators and distribution plan of 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 1.3925

　　2. Net assets per share (RMB) 7.9126

　　3. ROE (%) 13.54

　　2. Transfer 10 shares for every 10 shares.

　　78. (002194) Fangu, Wuhan: On April 2nd, an online briefing session on the 2007 annual report was held.

　　Wuhan Fangu is scheduled to hold an annual report briefing session on the online platform provided by Shenzhen Securities Information Co., Ltd. from 15: 00 to 17: 00 on Wednesday, April 2, 2008. The annual report briefing session will be held by remote network, and investors can log on to the investor interaction platform: http://irm.p5w.net to participate in this briefing session.

　　Present at the briefing session of this annual report were Mr. Meng Qingnan, Chairman of the Company, and others.

　　79. (002194) Wuhan Fangu: The 2007 Annual General Meeting of Shareholders was held on April 16th.

　　(I) Convenor of the meeting: the board of directors of the company.

　　(II) Convening time: 9: 30am on Wednesday, April 16th, 2008.

　　(3) date of record: April 10, 2008

　　(IV) Venue of the on-site meeting: No.1 conference room on the fourth floor of Denso Building of the company.

　　(V) Convening method: on-site voting method.

　　(VI) Matters considered at the meeting: 2007 Annual Report of the Company and its summary, 2007 Annual Profit Distribution Plan of the Company, etc.

　　80. (002204) Huarui Cast Steel: On March 31, 2007, an online presentation meeting on the annual performance was held.

　　Huarui Cast Steel will hold an online presentation on its 2007 annual performance on the online platform provided by Shenzhen Securities Information Co., Ltd. from 15: 00 to 17: 00 on Monday, March 31, 2008. This performance online briefing will be held in a remote way. Investors can visit Panorama http://irm.p5w.net to participate in the annual report briefing.

　　Present at the performance briefing were Mr. Song Jiajing, the chairman of the company, and others.

　　81. (002208) Hefei Urban Construction: The Board of Directors adopted the Articles of Association (amendment).

　　The 10th meeting of the 3rd Board of Directors of Hefei Urban Construction was held on March 24th, 2008, and the following resolutions were passed:

　　1. Rules of Procedure of the Board of Directors (Amendment);

　　2. Rules of Procedure for Shareholders’ General Meeting (Amendment);

　　3. Articles of Association (Amendment);

　　4. Work System for Independent Directors (Amendment);

　　5. Decision System for Related Party Transactions (Amendment);

　　6. Rules on Major Decision-making Procedures (Revised);

　　7. Management System of Raised Funds (Amendment);

　　8. Information Disclosure System (Amendment);

　　9. The Management System of Executive Stock Ownership and Its Change;

　　10. Investor Relations Management System;

　　11. Work System for Annual Reports of Independent Directors;

　　12. Work Rules for the Annual Report of the Audit Committee.

　　82. (002216) Sanquan Food: The board of directors passed the proposal of replacing the self-raised funds of the investment projects that have been invested with raised funds in advance with raised funds.

　　The 6th meeting of the 3rd Board of Directors of Sanquan Food was held on March 25th, 2008, and the following resolutions were passed:

　　I. Proposal on Replacing Self-raised Funds of Investment Projects with Raised Funds in advance.

　　II. Proposal on Resignation of Ms. Li Rong as Deputy General Manager.

　　83. (002219) Unique flavor: The 2007 annual general meeting of shareholders was held on April 18th.

　　1. Convening time: April 18th, 2008 (Friday) from 9: 00 am to 12: 00 am, with a duration of half a day.

　　2. date of record: April 11th, 2008.

　　3. Meeting place: Jiayuan International Hotel, No.181 Airport Road, Chengdu.

　　4. Convenor of the meeting: the board of directors of the company.

　　5. Meeting method: on-site voting.

　　6. Meeting topics: Proposal on Profit Distribution in 2007, etc.

　　84. (200152) Shandong Airlines B: The 2007 Annual General Meeting of Shareholders was held on April 22nd.

　　1. Meeting time: April 22, 2008 at 10:00 am, with a duration of half a day.

　　2. Meeting place: meeting room on the 31st floor of Shandong Aviation Building, No.5746, Second Ring East Road, Lixia District, Jinan.

　　3. Convenor: the board of directors of the company.

　　4. Convening method: on-site voting.

　　5. date of record: April 17, 2008

　　6. Matters considered at the meeting: 2007 Annual Report of the Company and its summary, 2007 Profit Distribution Plan of the Company, etc.

　　85. (200429) Guangdong Expressway A: Major events, the company’s shares were suspended from March 26th.

　　Guangdong Expressway A is planning major asset restructuring matters, and will provide policy consultation and scheme demonstration to relevant departments within five working days after the publication of this announcement, so there are still uncertainties in related matters.

　　In order to protect the interests of investors and avoid significant impact on the company’s stock price, the company’s stock was suspended from March 26, 2008 upon the company’s application.

　　86. (200488) Chenming Paper Co., Ltd.: It intends to continue to provide guarantee for the relevant holding subsidiaries to apply for the comprehensive credit line of RMB in 2008.

　　On March 24, 2008, the sixth meeting of the fifth board of directors of Chenming Paper reviewed and passed the "Proposal on Providing Guarantee for Holding Subsidiaries to Apply for Bank Credit Line". The 2007 annual credit guarantee provided by the company for its holding subsidiaries has expired one after another. In order to ensure the normal production and operation of each holding subsidiary, the company intends to continue to provide guarantee for the relevant holding subsidiaries to apply for the comprehensive credit line of RMB in 2008, with a total guarantee amount of 2.25 billion yuan and a term of one year.

　　87. (200530) Great Cold B: Abnormal fluctuations in stock trading.

　　The trading price of Dalang B stock was abnormal in the two consecutive trading days from March 24 to 25, 2008, which was a stock price change.

　　At present, the company does not have any matters or information that should be disclosed but not disclosed.

　　88. (200625) Changan Automobile: Main financial indicators and distribution plan of 2007 annual report.

　　I. Main financial indicators of the 2007 annual report

　　1. Earnings per share (RMB) 0.34

　　2. Net assets per share (RMB) 3.89

　　3. ROE (%) 8.81

　　2. Transfer 2 shares for every 10 shares.

　　89. (200625) Changan Automobile: The 2007 Annual General Meeting of Shareholders was held on April 25th.

　　(1) Convening time: 9:00 am on April 25th, 2008.

　　(II) Venue: Multimedia Meeting Room of Chang ‘an Science and Technology Building, No.260 Jianxin East Road, Jiangbei District, Chongqing.

　　(3) Convenor: the board of directors of the company.

　　(4) Convening method: on-site voting method.

　　(5) date of record: April 18, 2008.

　　(VI) Matters to be considered at the meeting: 2007 annual report and summary, profit distribution in 2007 and plan for converting capital reserve into share capital, etc.

Editor: Zhou Zhongxiao

　　The first episode of the large-scale TV feature film "Pilot" and the second episode of "Sailing at the helm" and "Science Guide" will be grandly launched on October 8 at 20: 00 on CCTV-1, the Central Radio and Television General Station, and CCTV news, CCTV video and CCTV network will be launched simultaneously.

　　In order to welcome the victory of the 20th Party Congress, Publicity Department of the Communist Party of China, together with the Central Party History and Literature Research Institute, the National Development and Reform Commission, the State Administration of Radio and Television, the Central Radio and Television General Station, the Political Work Department of the Central Military Commission and other units, produced 16 episodes of large-scale TV feature film "Pilotage". "Pilotage" focuses on the extraordinary and magnificent course that the CPC Central Committee with the Supreme Leader as the core unites and leads the whole party and people of all nationalities in the new era, shows the powerful truth power of the Supreme Leader’s Socialism with Chinese characteristics Thought in the great practice of the new era, comprehensively reflects the historic achievements and changes in the cause of the party and the country since the 18th National Congress of the Communist Party of China, and vividly presents the happy life and good spiritual outlook of the people in the new era.

The first episode of sailing at the helm

　　"Jiangshan is the people, the people are Jiangshan, fighting Jiangshan, guarding Jiangshan, and guarding the hearts of the people."

　　In February 2015, General Secretary of the Supreme Leader visited northern Shaanxi. When Liang Jiahe recalled the seven years of educated youth, he said with deep affection:"At that time, I said that if I had the conditions and opportunities in the future, I would go into politics and do something good for the people."

　　From the yellow land, from the village party secretary to the local leaders, and then to the leaders of the most populous country in the world, the General Secretary of the Supreme Leader always cares about the people.

　　"The people’s yearning for a better life is our goal."

　　Since he became the general secretary, he has traveled all over the country in many urban and rural areas, factories, mines, schools and communities, asking about the warmth and coldness, looking at the barn, uncovering the lid, and chatting at home.

　　Let the people live a happy life is the "big country" in the mind of the Supreme Leader General Secretary. He always remembers the daily necessities, food, clothing, housing and transportation of the people, one by one, and one by one.

　　In 2014, the Chairman of the Supreme Leader accepted an exclusive interview with Russian TV:"As national leaders, we have committed ourselves to many countries. We must be conscientious, feel at home, and stay up all night. There is a song called "Where has all the time gone?" Then my time has also gone to other places, which is obviously taken up by work. "

　　People lead and people love.

　　In November 2021, the Sixth Plenary Session of the 19th CPC Central Committee profoundly pointed out:

　　The Party’s establishment of the core position of the Party Central Committee and the whole Party, and the guiding position of the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era reflect the common aspiration of the whole Party, the whole army and the people of all ethnic groups throughout the country, which is of decisive significance to the development of the cause of the Party and the country in the new era and the historical process of promoting the great rejuvenation of the Chinese nation.

The second set of science guide

　　"I think that realizing the great rejuvenation of the Chinese nation is the greatest Chinese dream of the Chinese nation in modern times."

　　The Chinese Dream has given a new era connotation to the persistence and development of Socialism with Chinese characteristics, and injected inexhaustible power to unite and inspire hundreds of millions of Chinese people to forge ahead.

　　The pace of theoretical innovation of the party in the new era has also started.

　　Theoretical innovation and practical innovation promote each other and reflect each other.

　　From the Third and Fourth Plenary Sessions of the Eighteenth Central Committee to the Fifth and Sixth Plenary Sessions, the "four comprehensive" strategic layout has been laid out and gradually developed.

　　A series of original new ideas, new ideas and new strategies, the party’s theoretical innovation has made great achievements continuously, and a new theoretical system is ready to emerge.

　　The 19th National Congress of the Communist Party of China solemnly put forward Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era and wrote it into party constitution.

　　The first session of the 13th National People’s Congress passed a constitutional amendment, which enshrined the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era in the Constitution.

　　Just as a new era will not come in the natural evolution without historical initiative, new ideas are by no means created at the flick of a finger.

　　After the 18th National Congress of the Communist Party of China, in the face of new situations and new problems, the Supreme Leader General Secretary always has keen insight and in-depth research, and his research footprint is getting deeper and deeper.

　　Giving timely instructions on major issues reflected by all parties is an important way for the CPC Central Committee to govern the country and an important link to promote theoretical innovation.

　　Since the 18th National Congress of the Communist Party of China, a series of important instructions issued by the Supreme Leader General Secretary have vividly reflected the sensitivity and courage of policy makers, and also reflected the feeling that the people have a call and will respond.

　　Theory guides practice, and practice gives birth to theory. With the deepening of the great practice in the new era, the CPC Central Committee with the Supreme Leader as the core insists on respecting the initiative of the masses, concentrating the wisdom of the whole party, and constantly studying major issues that have a bearing on the overall situation and the long-term and making arrangements.

　　The Sixth Plenary Session of the 19th CPC Central Committee profoundly pointed out that the Supreme Leader’s Socialism with Chinese characteristics Thought in the new era is contemporary China Marxism and 21st century Marxism, and it is the essence of Chinese culture and China spirit, which has achieved a new leap in the China of Marxism.

　　Beijing, 11 Oct (Reporter Yu Yingbo) According to the General Administration of Quality Supervision, Inspection and Quarantine (AQSIQ) today, Samsung (China) Investment Co., Ltd. (hereinafter referred to as Samsung) has filed a recall plan with the bureau a few days ago, and decided to recall all SM-N9300 Galaxy Note 7 digital mobile phones sold in Chinese mainland from October 11, 2016, totaling more than 190,000 sets.

　　It is understood that the products within the scope of this recall may have serious consequences such as fire due to abnormal heating and burning. Statistics show that up to now, there have been 20 overheating and burning accidents in Chinese mainland. According to the "Legal Daily" reporter, since the "Samsung Explosion Door" incident, the General Administration of Quality Supervision, Inspection and Quarantine has interviewed Samsung at least twice.

　　The General Administration of Quality Supervision, Inspection and Quarantine said in the circular that in order to protect consumers’ personal and property safety, Samsung has stopped producing and selling SM-N9300 Galaxy Note 7 digital mobile phone products since October 10, 2016, and will take the following two measures to implement the recall: (1) Replace consumers with new Samsung mobile phones of other models for free, and refund the difference between the two products, and give a shopping voucher 300 yuan; (2) Refund in full according to the original purchase price, and recycle the products. Samsung promises that consumers can choose one of the above two ways. Samsung (China) Investment Co., Ltd. shall bear the postal expenses of the products produced by consumers due to their cooperation with this recall.

　　On the afternoon of 11th, Samsung apologized to China consumers for the loss of Galaxy Note7 through Weibo, saying that it decided to stop selling Galaxy Note7 products in Chinese mainland and recall all Galaxy Note7 products sold in Chinese mainland. Samsung expressed "sincere apologies" and "sincere apologies" at the beginning and end of the announcement.

　　On the same day, Samsung announced that it required operators and retailers around the world to stop selling Note7 mobile phones, and asked Note7 users to immediately shut down and stop using their mobile phones, including those who have original mobile phones or have completed replacement.

　　So far, from August 19th, Samsung released the new smartphone Note7, and on August 24th, it was exposed in South Korea. Up to now, it took 52 days. This incident was seriously damaged by Samsung’s corporate image, and all Note 7 products were recalled. The reporter talked with Liu Zhaobin, former chief engineer of AQSIQ, and the investigation time of Samsung defects will not exceed "sagitar broken shaft door"

　　□ Our reporter Yu Yibo

　　On October 11th, Samsung decided to recall 190,000 Note7 mobile phones sold in Chinese mainland, under the condition that the law enforcement supervision department of AQSIQ conducted an interview and started a defect investigation. Regarding this recall, the Legal Daily reporter interviewed Liu Zhaobin, former chief engineer of AQSIQ and director of Peking University Institute of Quality and Rule of Law.

　　Reporter: Under what circumstances can the General Administration of Quality Supervision, Inspection and Quarantine initiate interviews and defect investigations?

　　Liu Zhaobin: There are generally three situations to start an investigation: First, related injury accidents are found; Second, there are a large number of related complaints and reports; Third, there are similar batch product recalls abroad. In all three cases, a recall investigation can be initiated.

　　Reporter: What are the provisions of China’s current laws and regulations on starting defect investigation procedures? How many people and who are the "subjects" of defect investigation?

　　Liu Zhaobin: There are relevant provisions on the investigation procedures in the the State Council Order and the General Administration Order. The investigation is organized by the administrative organ, or the recall center is authorized to conduct the investigation. The survey is generally composed of managers, technical experts, etc., and laboratory inspection and appraisal are needed when necessary. The investigation is highly technical and complicated. It is not an easy task to accurately judge the specific state, causes and responsibilities of product defects, which requires a lot of painstaking and meticulous technical work.

　　Reporter: This defect investigation reminds people of the defect investigation of the new sagitar "broken shaft door" two years ago, which lasted for one year. According to your judgment, how difficult is this defect investigation? How long is it expected to last?

　　Liu Zhaobin: Automobile products are high-tech and complicated, and sometimes laboratory inspection reports are needed. The technical judgment of the reason should be repeatedly demonstrated, and the time may be longer. Although mobile phone products have high-tech content, they are still simpler than cars. I don’t think this survey will last long. Of course, it is not easy to find out the original cause.

　　Reporter: As one of the founders of this system, how do you evaluate the current defective product recall system? Any suggestions?

　　Liu Zhaobin: The recall system was jointly established by the General Administration of Quality Supervision, Inspection and Quarantine and relevant departments. I am only one of the participants. China’s recall system has been in operation for 12 years and achieved great results. The recall of more than 35 million defective cars has made great contributions to protecting people’s lives and property. Of course, this system needs to be further improved. In this regard, I have three suggestions: first, further improve the legislation and systematize the recall system. At present, the legal provisions are too scattered, the legal level is not high, the coverage is not wide, and the operability and scientificity need to be enhanced.

　　Second, strengthen implementation, strengthen centralization and unification, and standardize science. The vast majority of product recalls should be the responsibility of the central government, and should not be everywhere. Provinces, cities and counties are all arbitrarily recalling. In that case, there will be no unified big market. Even at the central level, dozens of ministries cannot each set up a recall system. It is necessary to prevent the system from splitting and preventing fragmentation. It is necessary to refine the recall procedures, recall standards, recall supervision and other norms, with the core goal of protecting consumers’ lives and property.　

　　Third, strengthen institutional guarantee. At present, the organization, establishment, funds, personnel and expert strength of recall management in China are far from enough to undertake such a large number of recall tasks. It is suggested that the state should attach great importance to it, increase investment, especially funds, and increase personnel as soon as possible in order to truly protect people’s lives and property.

　　China Consumers Association responds to Note 7 mobile phone recall. Samsung recall must protect consumers’ claims.

　　Beijing, Oct. 11 (Xinhua)-Reporter Yu Yingbo said today that Samsung should fully protect consumers’ rights and interests in the process of recalling mobile phones, in response to the newly released measures of "Samsung (China) Investment Co., Ltd. recalling SM-N9300 Galaxy Note 7 digital mobile phones".

　　A spokesperson for China Consumers Association pointed out that since the Samsung mobile phone incident, China Consumers Association has been paying close attention and maintaining close communication with relevant parties. Regarding this recall plan, China Consumers Association believes that Samsung should first inform consumers through various effective channels as soon as possible, including mass media, official websites and dealers at all levels, so as to fully protect consumers’ right to know.

　　The spokesman stressed that in the implementation of the recall plan, Samsung should try its best to make it convenient for consumers, avoid setting new obstacles for consumers in the product recall and protect consumers’ right to claim compensation. In addition, in the recall work, consumers should be treated fairly, avoiding favoritism and protecting consumers’ right to choose.

　　The spokesman also pointed out that Samsung should take this as a lesson, take consumer complaints seriously, honestly face product quality problems, actively examine the quality of other related products of the company, treat product quality and safety with the highest sense of responsibility, and safeguard consumers’ safety rights.

originate

Not long ago, the National Health and Wellness Commission and other six departments jointly formulated the "Second Batch of Rare Diseases Catalogue", which newly included 86 rare diseases. Together with the first batch of 121 rare diseases included in 2018, at present, there are 207 rare diseases included in the catalogue in China.

In recent years, the word "rare disease" has appeared more and more frequently in everyone’s field of vision. For example, in the news, the father developed "self-made medicine" for his son’s complex disease, and then in the past two years, the price negotiation of medical insurance was hot, and most of them were related to rare disease drugs.

The "drug god father", who was known on the Internet in 2021, took his son to be injected with gene therapy drugs in June 2022, and was also the first patient with Menkes disease who underwent gene therapy in China | See the watermark for the source.

In the past two years, the medical insurance price negotiations have always been hot headlines, and drugs related to rare diseases are included in the national medical insurance drug list every year | Source: CCTV News

Therefore, many people have the impression that the concept of rare diseases is both familiar and unfamiliar: rare diseases don’t seem so "rare", it seems difficult to treat them, and there don’t seem to be so many experts studying rare diseases …

But these superficial impressions are not enough to describe the whole picture of rare diseases.

What is a rare disease? Really "rare"?

In fact, different countries have different definitions of rare diseases. For example, the United States generally defines it as a disease with fewer than 200,000 people in China (that is, about 1 in 1,500), while the prevalence rate in Europe is less than 1 in 2,000.

According to China’s "Research Report on the Definition of Rare Diseases in China 2021", the definition of rare diseases in China is: "Diseases with neonatal morbidity less than 1/ 10,000, morbidity less than 1/ 10,000, and patients less than 140,000 are classified as rare diseases". The main reason is that China has a large population base. If the definition is too loose, the pressure on drug research and development and medical insurance will be too great.

Taking Europe as an example, different countries have different definitions of rare diseases, which often need to be considered according to factors such as population, drug research and development (the unit is every 100,000 people) | Source: Chung C C Y, et al. 2022.

You may be curious: since the prevalence rate is one thousandth or one thousandth, why do you say that it may be too loose to put pressure on the medical system? That’s because the concept of rare diseases is actually a collection of thousands of diseases, or collectively.

According to incomplete statistics, the number of known rare diseases is about 6000-8000. Although the prevalence rate is not all 1/2000, this figure is still very scary-according to the statistical estimation of the incidence rate of 3585 rare diseases, there are about 263-446 million people suffering from various rare diseases all over the world.

This is why, although it is called a rare disease, this group is not "rare" at all.

What does it mean to have a rare disease?

What does it mean to get this rare disease with a probability of one thousandth? Will it become a rare object that is taken care of by everyone like the stars holding the moon?

At least at present, most patients with rare diseases are not so lucky.

First of all, you have to diagnose what disease you are.

But in fact, the diagnosis of rare diseases is very difficult because of limited medical resources and imperfect medical knowledge. About half of the patients with rare diseases in the world still don’t know what disease they have, and the remaining half still face problems such as delayed diagnosis, wrong diagnosis, no treatment plan and unattended care.

What does this mean? If there is a rare patient in Europe, Xiao A, who suddenly has an attack, there is a 25% possibility that Xiao A will not know what disease he has until five years later. In 40% cases, different doctors will give Xiao A different diagnosis and different treatment schemes, and most of these treatment schemes are not helpful to Xiao A because of misdiagnosis.

However, under this wave of operation, Xiao A may have spent a lot of money to cure the disease.

"Layer-by-layer Screening" of Rare Diseases in Europe from Diagnosis to Treatment

In China, however, the shortage of medical resources will only make these ratios higher.

Suppose Xiao A was lucky enough to get an accurate diagnosis in just one year. At this time, the doctor turned over a long list of rare diseases and told Xiao A with regret that there was no medicine for your disease. Because now more than 90% of rare diseases have no good treatment.

This is also the reason why it was mentioned at the beginning that two years ago, the father could only develop drugs to treat his son himself.

As a result, Xiao A will fall into long-term hospitalization or drug treatment, not only can barely maintain his life, but also bear the sky-high medical expenses for life-for example, patients with cystic fibrosis need about 280-1.9 million euros in medical expenses for a lifetime.

Let’s assume that Xiao A is super lucky. Not only is he diagnosed quickly, but he also finds that this rare disease has a very effective orphan drug (rare disease is also called "orphan disease" because the patient is rare, just like "orphan"). As a result, ta may be shocked when he looks at the drug price: it is reported that the average price of rare disease drugs used by each patient is 4.8 times that of other diseases.

You can do a "simple math problem": in 2014, the development of a new drug in China will cost about $1.2 billion, and to maintain the research and development of the whole pharmaceutical industry, it is required that the sales volume should be at least $15 billion. According to the maximum subsidy of 300,000 RMB (about 50,000 US dollars) provided by medical insurance, at least 300,000 patients are needed-and a rare disease is defined as a disease with less than 140,000 patients. Then it requires higher pricing, so that drug researchers and the whole industry can "return to the original".

In other words, patients with rare diseases have to pay more for treatment than other patients.

What does it mean to study rare diseases?

But why are drugs for rare diseases so expensive? Are biomedical companies all black-hearted enterprises? In fact, it is not only patients, but also researchers of rare diseases.

However, the research on rare diseases in China is on the rise, even catching up with common diseases. The above figure shows the number of published research articles, and the following figure shows the number of clinical trials | Source: Yang L, et al.2015.

Suppose researcher Xiao B wants to study a rare disease. The first question Xiao B faces is: Where is my research object?

Although the definition of rare diseases is less than 140,000 people, it sounds like a large number, but in fact only a small number of patients will go to the hospital, and they are scattered in hospitals all over the country.

Not to mention finding a needle in a haystack, it should be as difficult as finding a needle in a swimming pool.

Let’s continue to assume that Xiao B is lucky enough to collect information about dozens of patients with rare diseases in several hospitals and prepare for research. At this time, the question comes again-where does the research funding come from? Rare diseases are mostly genetic diseases, and the study of rare diseases requires gene sequencing, data analysis, animal experiments and so on, which require no less funds than ordinary diseases.

However, from the simple relationship between supply and demand, patients with more common diseases often get more financial support; However, there are more than 5,000 rare diseases with different pathogenesis, so much research funds are available, and what researchers can get is often a drop in the bucket.

From diagnosis to research and development of rare diseases, every step is money, especially when ordinary sequencing (exon sequencing, ES) is ineffective, it is more complicated for researchers to judge the difficulty and exploration direction of rare diseases | Source: Marwaha S, et al. 2022.

However, assuming that Xiao B is lucky, he just applied to the National Natural Science Foundation of China, which has started to increase funding for research on rare diseases in recent years, and got a lot of research funds. Xiao B intends to do a big job to develop an effective drug for this rare disease and solve this rare disease once and for all!

So Xiao B collected patient information, sequenced to find rare disease targets, and began to screen different drugs;

After discovering hundreds of drugs that may be useful, carry out cell experiments and animal experiments;

Finally, five drugs may be effective, so they went to clinical trials;

After the first phase, the second phase and the third phase of the clinic, I was particularly lucky that a drug was proved to be effective;

Start the long drug approval and enter the fourth phase of clinical practice;

Finally, the drug was put into use.

So more than ten years have passed.

Process of new drug research and development | Source: Shanghai Institute of Pharmacology, China Academy of Sciences

In addition, the results brought by the small sample size of patients are unreliable, the experimental design is difficult, and the treatment is not necessarily extensive and effective, which are puzzling the researchers of rare diseases.

It can be seen that it is a thankless thing for researchers to study rare diseases and develop related new drugs.

We can’t ignore it just because it’s "rare"

However, we can’t ignore hundreds of millions of patients with rare diseases because rare diseases are rare, or because research is "thankless".

For patients, governments all over the world have gradually realized the importance of rare diseases, and have increased investment in relevant medical insurance policies, so that more and more patients can get the best treatment at acceptable prices. There was also a hot search for high-priced drug negotiations in the previous two years.

By the end of this year, more than 50 kinds of 75 kinds of drugs for rare diseases that have been approved for listing in China have been included in the medical insurance drug list.

The status quo of rare disease drugs included in medical insurance | Source: Comprehensive report on rare diseases

For the drug research of rare diseases, different countries often support the development of rare diseases drugs from the aspects of research and development funds, drug approval cycle, drug tax relief and so on. In recent years, China has also improved the laws and regulations in this area to better support the research of rare diseases in China.

From the end of last century, governments and research institutions in various countries gradually realized that rare diseases are not rare, and they also deserve public attention. From diagnosis to treatment, from research to drugs, there are more and more different supports, but in the face of 300 million patients and thousands of diseases, the progress now is far from enough.

As a trivial biological science popularization person, we also hope to make a contribution in this respect. Now that China has listed 207 rare diseases, we will try to introduce these "orphan diseases" in simple and easy-to-understand language, which you may have never heard of.

I believe that as long as everyone knows something, orphan disease will no longer be lonely.

References:

? Chung C C Y, Hong Kong Genome Project, Chu A T W, et al. Rare disease emerging as a global public health priority[J]. Frontiers in public health, 2022, 10: 1028545.

The Third Multidisciplinary Expert Seminar on the Definition of Rare Diseases/Orphans in China, Research Report on the Definition of Rare Diseases in China 2021.

Comprehensive report on lilac orchard and rare diseases

? Ferreira C R. The burden of rare diseases[J]. American journal of medical genetics Part A, 2019, 179(6): 885-892.

? Yang L, Su C, Lee A M, et al. Focusing on rare diseases in China: are we there yet? [J]. Orphanet journal of rare diseases, 2015, 10(1): 1-2.

? Griggs R C, Batshaw M, Dunkle M, et al. Clinical research for rare disease: opportunities, challenges, and solutions[J]. Molecular genetics and metabolism, 2009, 96(1): 20-26.

Read the original text

Special feature of 1905 film network Chinese New Year movies are booming. At present, six films have been scheduled for the New Year’s Day, and the pattern of the Spring Festival in 2024 has basically taken shape. There is no doubt that this will be another "multi-power competition". Among many excellent films, which one do you look forward to most?

Regarding "What movie are you most looking forward to in the Spring Festival of 2024", Film Critics Today released a questionnaire poll, and counted the voting data of 50 film critics and more than 500 netizens. Let’s take a look at the voting results!

Film critics’ voting: more expected by professionals

Among the voting results of 50 professional film critics, the top three films that most want to see are YOLO’s The Movie Emperor and Article 20, both of which have gained more than 50% support rate.

The reasons why professional film critics want to see it mainly focus on the creative characteristics of the film and the trust and expectation of senior filmmakers.

Undoubtedly, the voting results of film critics also reflect the expectations in the market to some extent. After YOLO booked the file, he boarded the hot search list of Weibo for 17 times, and the long-lost civil servant announced his return with a new film, which instantly ignited the audience’s discussion.

"Article 20" also appeared on the hot search list of Weibo for 12 times after it was finalized. The hearing-impaired people played in the trailer brought great surprises and expectations to the audience. From the platform data, the film "The Movie Emperor" is also very popular and expected by a city line audience.

Audience voting: the announcement was the first and impressive.

In the Weibo poll of #2024 Spring Festival, which movie do you most expect to see #, "Pegasus 2" is far ahead of other films with more than 430 votes.

Pegasus 2 was the first official Spring Festival movie released last week, and the popular variety "Ace to Ace" also aired a special program of Pegasus 2 last week, so this film will have some first-Mover advantage in publicity and play a certain preconceived impression.

Judging from the audience of the film, Pegasus 2 is the only film that men want to see, and the theme of racing is more favored by male audiences. In addition, there are two generations of "conspicuous packages" with national characteristics &mdash; &mdash; And also attracted a lot of audience, I believe that the two of them will also give the audience a lot of burdens and jokes in the film.

In addition, it is worth mentioning that among the six films currently scheduled, the film that young viewers under the age of 25 want to see most is Article 20. Among the portraits they want to see in this film, young viewers under the age of 25 account for the highest proportion, reaching 42.5%.

Data analyst analysis: the steady "Bear Haunted" became the "judge" of the Spring Festival file

Chen Jin, a professional data analyst, also gave his opinion on this "multi-strong competition" of the Spring Festival file. "I believe the final box office ranking of this year’s Spring Festival file is no small suspense, but no matter how others fight, the most stable one should be the tenth film in the series" Bears haunt ".

The ten years’ hard work in the Spring Festival has brought it a steady box office performance. The so-called "Flowing Spring Festival file, the iron-clad" Bear Haunted "and" Bear Haunted "have also become the judges of whether the box office of other films in the Spring Festival file is" big bang ".If the box office of the film can be higher than" Bear Haunted ",then this film is likely to reap the schedule bonus of the Spring Festival file.

According to the data of the platform, there are three films that want to see more people than Boonie Bears: Time Twist, namely YOLO and Article 20. Relatively speaking, these three films are more likely to get good box office results. In addition, The Movie Emperor also hopes to achieve a box office counterattack through word-of-mouth spread in the later period.

This year’s Spring Festival has an eight-day long holiday, which has surpassed any previous Spring Festival stalls in terms of time. At present, six films have been booked. I hope they can enhance the popularity of the films through some ceremonial, innovative and effective announcement actions and some efficient communication strategies, so as to achieve a good result. We also expect that the Spring Festival file of this year’s eight-day holiday will bring a surprise box office result.

The Spring Festival is a miracle-filled schedule. I hope that this year’s Spring Festival will also continue the steady performance of the previous Spring Festival, create a new schedule record, and inject a shot in the arm into the China film market in 2024!

▽ The egg at the end of the text! The film most anticipated by film critics in 2024 Spring Festival and its reasons

1905 movie network news The special official announcement of the romantic fantasy film Tanabata, which was jointly created by, directing, starring, starring and the original crew of the same name drama series, released the "reunion" version of the pilot notice and the "star in the eye" version of the pilot poster, and announced that it would meet the audience at the New Year’s Eve. The Milky Way flows, and Zhang Wansen and Lin Beixing are once again in the same frame, which makes this hard-won reunion full of beautiful heart atmosphere. The phrase "those regrettable moments, we filled them with reunion" is meaningful, which makes many people feel curious about the movie plot, and they are increasingly looking forward to meeting with the pure love story of Wanxing CP in this year’s New Year’s Eve, which makes the past meaning difficult to calm down in the snowy season.

Wanxing CP Tanabata Surprise Reunion Qu Chuxiao Karlina has a deep sense of destiny.

In the preview of the film released today, Zhang Wansen and Lin Beixing finally reunited. They looked at each other face to face with deep affection and showed a relieved smile, but they couldn’t help but burst into tears. A choked "long time no see" was worth a thousand words, which condensed their infinite concern for each other, and their emotions were set off to the extreme in just 15 seconds. If the preview vividly explains the mixed feelings of the reunion moment, then the poster is more like the sweetness and beauty after the reunion. In the poster, Zhang Wansen and Lin Beixing stand together, with their backs against the beautiful beach and dazzling neon. At this moment, they are the most dazzling beings in each other’s eyes, and the lamps behind them are just arranged in the words "Shining For One Thing", which is a romantic annotation of their feelings.

It’s the Qixi Festival, and the pure love atmosphere that comes from the previews and posters is very appropriate. At the same time, it also brings comfort and hope to many drama powders. The drama version of the story has deeply abused countless people by virtue of BE aesthetics. After reading it for a long time, it is hard to let go. The audience can’t bear to see the secret love story of Zhang Wansen and Lin Beixing, leaving regrets, and the expectation that they will meet again has reached its peak. The latest material of the film is just a warm response to the audience’s expectations. "Those moments of regret, we filled them with reunion" seems to be the tacit understanding of Wanxing CP. And in this meaningful.After the big reunion, how will the fate of the two people extend? Can they really break through the obstacles and make all the regrets complete? All kinds of suspense are left to be revealed in the future.

"Secret love for the ceiling" super after-sales New Year’s Eve strikes, igniting feelings and agreeing to go to snow with the audience.

The explosive drama series "Twinkle, Twinkle, Twinkle, Bright Stars" of the same name once broke the box office record of platform and broadcast period, won the love of countless audiences and spontaneously Amway, and became the dark horse of the year 2022. After a year, the film version started shooting in the long expectation, and it was reassuring that the original team returned again. Drama fans have speculated when the film will meet the audience, and finally hoped for the good news of reunion on Tanabata. This reunion not only represents the reunion of Zhang Wansen and Lin Beixing in the preview, but also symbolizes the long-lost reunion between the story of Twinkle, Twinkle and Bright Stars and the audience, which is a two-way trip between the film and the audience. The film promised the audience a romantic agreement of "reunion on New Year’s Eve", which evoked many viewers’ inner feelings for a time. Once upon a time, the phrase "Zhang Wansen, it’s snowing" once spread all over social platforms, and became a classic line like Bai Yueguang in the minds of countless people. Now, I can finally get to Zhang Wansen’s pure love appointment with Lin Beixing in the snowy season, which is undoubtedly a dream-fulfilling plan full of ritual for the majority of drama fans. Not only that, we can make a New Year’s Eve appointment on Tanabata, and this romance will accompany us all the way, from summer to winter. Many dramas can’t hide their joy, saying that "I really want to watch the first snow of the New Year with Zhangwan Forest North Star in the cinema", "This year’s New Year’s Eve’s pure love warrior must keep an appointment", and "See you on Chinese New Year’s Eve, sparkling is a sense of ceremony" &hellip;&hellip; More and more people meet to enter the cinema in New Year’s Eve, witness this sincere and pure love together, gain the comfort of "love reverberates", and look forward to "2024 can go with happiness and happiness in both directions". I believe that this warm and romantic "pure love energy" will definitely turn into the best blessing on the occasion of the arrival of the New Year, reaching the deep heart of every audience and bringing the most unforgettable viewing experience.

The film Twinkle, Twinkle, Twinkle, Bright Stars is directed by Feng Wang, produced by Wang Chen, directed by Chen Xiaoming and Zhang Pan, written by Zhang Pan, Duan Yule, Wang Yichao and Chen Xiaoming, starring Qu Chuxiao and Karlina, and starring Jinna and Jiang Yunlin. The film is being filmed, and I look forward to meeting the national audience for the New Year.

　　CCTV News:The honor guard of the Chinese People’s Liberation Army (PLA), as the only unit in China that undertakes the task of ceremonial ceremonies at the national level, has long been a shining national business card for its vigorous pace and upright posture. And behind every appearance, how are the honor guards selected and trained? Let’s get to know each other.

　　The honor guard of the Chinese People’s Liberation Army (PLA) is a ceremonial unit that mainly carries out the task of ceremonial ceremonies, and is mainly responsible for the welcoming ceremony held by the leaders of the party, the state and the military for foreign heads of state, heads of government and senior military generals when they visit China.

　　Han Jie, the captain of the honor guard of the Chinese People’s Liberation Army, said that to be an honor guard, we must first meet the requirements of People’s Republic of China (PRC)’s military service law. On this basis, there are some special conditions for the selection of our honor guards. For example, the height of male players should reach more than 1.80 meters, and the height of female players should reach more than 1.73 meters. Their daily performance should be good, their bodies should be symmetrical and their facial features should be correct.

　　Reporter Zhou Su said, I am now in the training ground of the honor guard of the Chinese People’s Liberation Army. Behind me, the officers and men are training step by step and step by step. This kind of training is done day after day and year after year, just to show the honor guard the best in all major tasks.

　　One minute in front of the stage and ten years behind the scenes, all the accurate queue movements of the honor guards come from thousands of repetitions and polishing.

　　Members of the honor guard of the Chinese People’s Liberation Army said that I had participated in the military parade for 15 years. At that time, the longest standing posture was five hours. From 9: 00 am to 2: 00 pm, I stood dizzy and uncomfortable. Finally, I persisted.

　　Players wear out 7 pairs of boots per year.

　　March forward with the military career of every honor guard. The soldiers told reporters that each of them wears out an average of seven pairs of boots every year, and all of them have worn-out scars on their feet. The cumulative distance of marching in the three years is equivalent to one or several miles of the 25,000-mile long March, and the annual sweat is nearly one ton.

　　The members of the honor guard of the Chinese People’s Liberation Army said that because they wear riding boots, which are relatively long, with wood under them, they walk for a long time, and their heels are easy to wear out and bleed, so there is no way. I will continue to insist (when performing tasks), and soldiers must insist.

　　The players face the wind for 30 seconds without blinking or crying.

　　As a symbol of the country, the honor guard is the glory of the army. When facing foreign guests, every guard of honor needs to be radiant and natural. During the training, the soldiers should not blink or shed tears for 30 seconds under the condition of facing the wind and the light. In order to keep the best state in all tasks, the guard of honor also needs to carry out targeted expression and eye training.

　　Members of the honor guard of the Chinese People’s Liberation Army said that the requirement of our honor guard for the honor guard is that we don’t blink for 45 seconds. In summer, we practice in front of the sun, and in winter, we practice against the cold wind, so every soldier can keep the wind blowing and the sand playing.

　　It is understood that the honor guard of the Chinese People’s Liberation Army has successfully completed more than 4,000 ceremonial ceremonies since its establishment more than 60 years ago. At all times, it has completed various major tasks with high quality with the standard that appearance is wonderful and appearance is shocking, fully demonstrating the era style of the whole party, the whole army and the people of the whole country to forge ahead in a new era and start a new journey.

Special feature of 1905 film network Last year, on the National Day, Dapeng filmed the feelings and charm of guitar music with a "Sewing Machine Band". In the film, the passionate performance of the band members in the "Big Guitar Square" has infected countless audiences.

The movie ended, and the big guitar square in Sewing Machine Band no longer exists. However, in Guizhou, thousands of kilometers away from the northeast, a county named Zheng ‘an is staging its own inspirational story of poverty alleviation with the help of handfuls of small guitars.　

　

Zheng ‘an, located in the hinterland of Wuling Mountain in northern Guizhou, is a national key poverty alleviation and development county under the jurisdiction of Zunyi City, Guizhou Province.

　

Walking in this small town surrounded by mountains, you will find that street lamps on both sides of the road, fountains in convenience parks and humanistic sculptures everywhere are full of exquisite "guitar" elements, which have been closely linked with the cultural life of Zhengan people.

　

What kind of "fate" is this? On September 27th, we just arrived in Zheng ‘an to participate in the "Fight Against Poverty &mdash; &mdash; Team Yao Chen, an actor in the fourth stop of the "Starlight Action" charity event, listened to the introduction of the relevant person in charge of the local county government at the poverty alleviation research and planning meeting.

　

Everything starts with a decision made by the county five years ago. In 2013, Zheng ‘an County seized the opportunity of industrial transfer in coastal areas and introduced the guitar manufacturing enterprises originally located in Guangzhou into its own home, making the guitar manufacturing industry gradually become an important starting point for local industries to help the poor.

　

Now, after several years of development, Zhengan has built the world’s largest guitar production base, and 26 enterprises have successively entered the guitar industrial park, with an annual output value of over 1.5 billion. In addition to the advanced cloud data center and modern production workshop covering an area of more than 600,000 square meters, the guitar culture theme park here will also help Zhengan to truly realize the industrial upgrading from industrial production to manufacturing, culture and tourism.

　

Talking about the local cultural development, Cheng Xiaoqiu, deputy secretary of the Party Working Committee of Guizhou Zheng ‘an Economic Development Zone, specially introduced the guitar cultural square which is popular in the local area.

The design of the square coincides with the big guitar square in Sewing Machine Band, which is also dominated by several giant guitar symbols. Every evening, the local people like to relax there, overlooking the night scene of the square, and the lights also outline the shape of the guitar on the ground, which is full of design.

　

Hearing this, Yao Chen, who usually likes music, showed great interest. As soon as they left, the group set off directly from the planning meeting site and went to this guitar culture square, which can be called the absolute "bright spot" in Zheng ‘an County.

Although it rained in the sky, there were still many people gathered in the square. Everyone was scattered around the guitar playing groups, feeling the music and enjoying the comfort of the night in the small town.

　

The first group of performers Yao Chen met was the local children’s guitar band "Orange Band", the oldest of whom was only 18 years old. Taking the opportunity of learning guitar playing, several teenagers got together and formed this band "The sparrow is small but complete".

Usually, they often perform for their classmates at school. Chen Qin, a guitarist, told us that every time she heard her classmates sing along with her piano, she would feel very happy.

　

Further on, Yao Chen was suddenly attracted by an absolute "budding guitarist". On the bench, a little girl with a double ponytail is seriously playing a "little guitar" that is very commensurate with her. The immature children’s voice hit everyone present at once.

　

The little girl is 5 years old and has been studying guitar playing for more than a month with her parents who love music. Seeing Yao Chen, she shyly took out a gift for "Little Potato", and Yao Chen happily took it and opened it on the spot. It turned out to be the "Little Guitar" played by the little girl &mdash; &mdash; Ukulele Yao Chen not only gladly satisfied the little girl’s wish to take a group photo, but also sent her an invitation: "Welcome to Beijing, ok?"

　

In addition to children who like guitar and love music, there are more players from all walks of life in this guitar culture square, expressing their feelings for Zheng ‘an through their guitars. Li Xu and Zheng Song, poverty alleviation cadres, and two local teachers have formed a special "poverty alleviation cadre band".

　

Li Xu has a personal experience in his own poverty alleviation work for Zheng ‘an’s efforts to develop through guitar manufacturing, a pillar industry in the past five years. The continuous construction and growth of guitar production bases has helped more young laborers in counties to find jobs at home, which has greatly promoted the progress of local poverty alleviation.

　

Along with it, there are also local cultural industries. Li Xu saw that more and more people began to learn and play the guitar with the continuous integration of guitar into local people’s lives. There are more and more guitar playing educational institutions in the county. "Many children go to school, which can not only cultivate interest, but also make a group of talents in the future."

　

Due to the busy daily work, the band of poverty alleviation cadres seldom get together to perform, but Zheng Song always puts a guitar in his dormitory and plays a song when he is free, which is the best way to relax.

　

I felt a round of Zheng ‘an people’s enthusiasm for guitar at close range in the square, which made Yao Chen more curious about this instrument. At the planning meeting, Yao Chen and the research team decided on tomorrow’s itinerary. At that time, she will go to the guitar production base to experience the whole process of a piano from material processing to product delivery.